larotrectinib will increase the degree or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.

Modafinil’s outcomes are related in certain ways to All those of conventional stimulants, but its distinctive mechanisms of action established it apart.

anastrozole will improve the level or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.

mitotane decreases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a solid inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for probable dosage changes.

elvitegravir/cobicistat/emtricitabine/tenofovir DF boosts levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

eslicarbazepine acetate will boost the degree or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe.

Modafinil is often a wakefulness-promoting agent with established nootropic Attributes. Its effectiveness is nicely-documented in dozens of experiments above a long time of research, and It really is usually made use of off-label by healthful individuals who want to improve their psychological effectiveness.

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modafinil will reduce the level or impact of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Sturdy or moderate CYP3A4 inducers may well increase fee of diazepam elimination; therefore, efficacy of diazepam could be lowered.

itraconazole will improve the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Chance of skin reactions, Steven-Johnsons Syndrome, harmful necrolysis, and drug rash with eosinophilia and systemic signs and symptoms; discontinue if rash or other hypersensitivity reactions happen

Keep track of Intently (1)crofelemer boosts amounts of modafinil by affecting hepatic/intestinal get more info enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the prospective to inhibit CYP3A4 at concentrations predicted from the intestine; not likely to inhibit systemically for the reason that minimally absorbed.

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